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Table 2 Genes annotated to the top replicated DARs

From: Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

Symbol

Region Annotation

CHR

Region

Location

Peak

Location (PW, NBB)

MetaP

LFC

PW, NBB

PeakName

PW, NBB

Proportion

Significant

Common hypoacetylated regions

PTPRH

introns

19

55,718,568–55,720,750

55,720,288–55,722,414, 55,717,912–55,719,103

1.7E-07

−0.81, −0.94

Peak_20188, Peak_15767

3p/4 (0.8)

JUP

introns

17

39,681,526–39,923,630

39,805,764–39,808,133, 39,807,092–39,808,006

1.1E-05

−0.43, − 0.99

Peak_53983, Peak_81536

5p/10p (0.5)

Common hyperacetylated regions (top 15)

DLG2a

exons

11

83,874,504–83,874,554

83,873,551–83,879,844, 83,873,666–83,877,544

7.7E-12

0.68, 1.05

Peak_21808, Peak_40741

30p/49p(0.6)

KIT

exons

4

55,604,595–55,606,881

55,606,747–55,609,274, 55,606,782–55,609,553

8.1E-11

0.63, 1.26

Peak_21777, Peak_37103

2/3p (0.7)

CNTNAP2

exons

7

147,336,198–147,336,398

147,333,973–147,338,260, 147,333,944–147,337,213

6.2E-09

0.51, 1.07

Peak_44999, Peak_47588

11/18p (0.6)

RNF216

introns

7

5,681,008–5,692,043

5,679,685–5,685,127, 5,688,370–5,705,729

1.2E-08

0.6, 0.53

Peak_38631, Peak_12618

11p/16 (0.7)

FRMD5

introns

15

44,216,508–44,393,656

44,260,324–44,263,821, 44,244,249–44,247,825

1.6E-08

0.68, 0.67

Peak_18018, Peak_18744

12p/17p(0.7)

SOX2-OT

introns

3

181,328,718–181,417,385

181,358,880–181,360,150, 181,341,154–181,348,014

1.7E-08

0.55, 0.91

Peak_43667, Peak_31549

9/12 (0.8)

MAGI2

1to5kb

7

78,120,338–78,124,337

78,121,257–78,128,843, 78,115,190–78,121,170

2.2E-08

0.4, 0.93

Peak_18816, Peak_24042

9p/23 (0.4)

PPP2R2B

introns

5

146,080,706–146,460,621

146,383,635–146,384,203, 146,459,075–146,469,815

2.8E-08

1.3, 0.52

Peak_135972, Peak_17645

17p/27p(0.6)

KCNH1

introns

1

210,948,887–210,970,849

210,966,438–210,969,215, 210,946,491–210,950,181

3.8E-08

0.55, 1.0

Peak_51838, Peak_38212

9/18p (0.5)

CDH1

introns

16

68,835,797–68,842,326

68,840,159–68,841,130, 68,782,065–68,837,136

4.8E-08

0.84, 0.37

Peak_66179, Peak_3389

5/7p (0.7)

MAP 4 K4a

introns

2

102,315,001–102,407,181

102,330,963–102,334,475, 102,367,013–102,375,949

5.2E-08

0.54, 0.62

Peak_30093, Peak_9009

10p/24p(0.4)

METTL24

introns

6

110,644,076–110,729,536

110,656,829–110,661,962, 110,685,537–110,688,887

5.4E-08

0.48, 0.97

Peak_22739, Peak_27591

8/13p(0.6)

PIP4K2A

introns

10

22,898,647–23,003,111

22,934,570–22,952,399, 22,957,818–22,962,517

5.6E-08

0.58, 0.52

Peak_22480, Peak_27954

9p/18p(0.5)

SIK3

introns

11

116,827,781–116,968,858

116,825,819–116,835,556, 116,846,923–116,884,577

5.8E-08

0.6, 0.49

Peak_21504, Peak_11226

13p/16p(0.8)

DOCK10

introns

2

225,796,386–225,906,968

225,798,681–225,800,264, 225,845,772–225,849,871

8.1E-08

0.61, 0.77

Peak_94440, Peak_22866

6/10p(0.6)

Common hyperacetylated regions (additional GWAS hits)

CRHR1a

introns

17

43,707,525–43,750,192

43,726,544–43,728,643, 43,741,886–43,747,152

2.0E-07

0.43, 0.83

Peak_74390, Peak_30944

6/14p(0.4)

MBNL2a

introns

13

97,873,814–97,927,885

97,919,075–97,922,481, 97,906,667–97,916,758

1.2E-05

0.44, 0.44

Peak_29656, Peak_16279

14p/22p(0.6)

  1. For hyperacetylated regions, the top 15 genes with DARs common to the two cohorts and common DARs in genes previously associated with PD are shown. The genes were ranked based on Fisher’s meta p-value. The full list of genes is provided in Supplementary Table S6
  2. aPrevious association with PD based on GWAS; Region Location – genomic location (on the indicated chromosome) of the annotated region; Peak location – genomic location of the relevant peak from each cohort (upper – PW, lower - NBB); LFC – log fold change compared to controls; Peak Name – the peak identifier in each cohort; Proportion significance – DARs/total common regions annotated to the gene; p- peaks annotated to promoter region of the gene