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Table 2 Participant characteristics separated by brain amyloid status

From: A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis

  Amyloid Negative (N = 253) Amyloid Positive (N = 161)
Age (P < 0.0001)
 Mean (SD) [N] 67.7 (8.1) [253] 73.6 (7.4) [161]
Sex (P = 0.0139)
 Female [N] 63.6% [253] 50.9% [161]
Ethnicity (P = 0.5734)
 Hispanic [N] 21.7% [198] 24.5% [110]
Race
 White 176 97
 Black or African American 8 5
 Asian 2 0
 American Indian or Alaska Native 1 1
Education (P = 0.4080)
 Mean years (SD) [N] 16.3 (2.4) [170] 16.1 (2.5) [85]
ApoE4 distribution within subgroup
 No E4 [N] 71.5% [181] 32.3% [52]
 One E4 [N] 21.7% [55] 50.9% [82]
 Two E4 [N] 6.7% [17] 16.8% [27]
CDR (P < 0.0001)
 Percent CDR = 0 [N] 79.8% [84] 32% [75]
MMSE (P < 0.0001)
 Percent MMSE = 27–30 [N] 95.4% [152] 60.6% [71]
 mean (sd) 29.4 (1.6) 26.2 (4.5)
Abeta42/40 (P < 0.0001)
 mean (sd) 0.101 (0.010) 0.090 (0.010)
 min 0.072 0.059
 max 0.126 0.148
Abeta42 (pg/mL) (P < 0.0001)
 mean (sd) 44.477 (8.637) 40.421 (9.698)
 min 10.984 23.985
 max 82.494 103.882
Abeta40 (pg/mL) (P = 0.22)
 mean (sd) 440.435 (81.870) 452.325 (103.933)
 min 134.985 270.455
 max 893.672 1219.238
  1. N Number of total observations - not all demographic data were available from each cohort, so [N] is the number of participants where data was available/provided