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Table 1 Summary of Reviewed Variants and Genes

From: Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions

rsIDa

Alleleb

CPRAb

MAFc

Gene

Evidence

Reference

rs63750847

C > T

21:27269932:C:T

0.0001

APP

Strong

[42]

rs7412

C > T

19:45412079:C:T

0.087

APOE-ε2

Strong

[43]

rs121918393

C > A

19:45412013:C:A

0

APOE3ch

Moderate

[33]

rs9536314

T > G

13:33628138:T:G

0.147

KL (Klotho-VS)

Moderate

[44]

rs9527025

G > C

13:33628193:G:C

0.168

KL (Klotho-VS)

Moderate

[44]

rs10553596

T > −

10:115439641:T:-

0.19

CASP7

Moderate

[45]

rs2230806

C > T

9:107620867:C:T

0.29

ABCA1

Strong

[46]

rs72973581

G > A

19:1043103:G:A

0.05

ABCA7

Strong

[47]

rs11218343

T > C

11:121435587:T:C

0.052

SORL1

Moderate

[48]

rs142787485

A > G

2:26358156:A:G

0.0406

RAB10

Modest

[49]

rs3851179

T > C

11:85868640:T:C

0.361

PICALM

Modest

[50]

rs3796529

C > T

4:57797414:C:T

0.194

REST

Moderate

[51]

rs72824905

C > T

16:81942028:C:T

0.007

PLCG2

Moderate

[32]

rs3747742

T > C

6:41162518:T:C

0.306

TREML2

Moderate

[31]

rs1990621

C > G

7:12283873:C:G

0.447

TMEM106B

Modest

[52]

  

MS4A cluster

Modest

[53]

  

BDNF

Strong

[54]

  

Dlgap2

Moderate

[41]

  1. Abbreviations: CPRA chromosome, position, reference allele, alternative allele, MAF minor allele frequency
  2. arsID is given for all variants except for reviewed genes whose wild-type forms are protective or for those in a multi-gene cluster (major > minor)
  3. bAllele information from dbSNP (https://www.ncbi.nlm.nih.gov/snp/) and/or confirmed in the referenced literature
  4. cMinor allele frequency information from dbSNP (ALFA project - global, https://www.ncbi.nlm.nih.gov/snp/docs/gsr/alfa/) and/or confirmed in the referenced literature