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Table 1 Summary of Reviewed Variants and Genes

From: Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions

rsIDa Alleleb CPRAb MAFc Gene Evidence Reference
rs63750847 C > T 21:27269932:C:T 0.0001 APP Strong [42]
rs7412 C > T 19:45412079:C:T 0.087 APOE-ε2 Strong [43]
rs121918393 C > A 19:45412013:C:A 0 APOE3ch Moderate [33]
rs9536314 T > G 13:33628138:T:G 0.147 KL (Klotho-VS) Moderate [44]
rs9527025 G > C 13:33628193:G:C 0.168 KL (Klotho-VS) Moderate [44]
rs10553596 T > − 10:115439641:T:- 0.19 CASP7 Moderate [45]
rs2230806 C > T 9:107620867:C:T 0.29 ABCA1 Strong [46]
rs72973581 G > A 19:1043103:G:A 0.05 ABCA7 Strong [47]
rs11218343 T > C 11:121435587:T:C 0.052 SORL1 Moderate [48]
rs142787485 A > G 2:26358156:A:G 0.0406 RAB10 Modest [49]
rs3851179 T > C 11:85868640:T:C 0.361 PICALM Modest [50]
rs3796529 C > T 4:57797414:C:T 0.194 REST Moderate [51]
rs72824905 C > T 16:81942028:C:T 0.007 PLCG2 Moderate [32]
rs3747742 T > C 6:41162518:T:C 0.306 TREML2 Moderate [31]
rs1990621 C > G 7:12283873:C:G 0.447 TMEM106B Modest [52]
   MS4A cluster Modest [53]
   BDNF Strong [54]
   Dlgap2 Moderate [41]
  1. Abbreviations: CPRA chromosome, position, reference allele, alternative allele, MAF minor allele frequency
  2. arsID is given for all variants except for reviewed genes whose wild-type forms are protective or for those in a multi-gene cluster (major > minor)
  3. bAllele information from dbSNP (https://www.ncbi.nlm.nih.gov/snp/) and/or confirmed in the referenced literature
  4. cMinor allele frequency information from dbSNP (ALFA project - global, https://www.ncbi.nlm.nih.gov/snp/docs/gsr/alfa/) and/or confirmed in the referenced literature