Fig. 1
From: Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy
Il10 and Il6 levels in the brain and plasma. a Schematic representation of experimental paradigm. Neonatal TgCRND8 mice were bilaterally injected ICV with pAAV2/1 (4 × 1010 genomes) expressing Il6 or Il10 cytokines. Control mice were injected with pAAV2/1-GFP. At 2-months-old mice were divided into two groups that were immunized bi-weekly with 500 µg of mAb5 or mouse IgG. b 6-month-old mice were sacrificed and brains were harvested (n = 6–12). Brain levels of Il6 and Il10 were measured by ELISA. Data represent mean + SEM. *p < 0.01, **p < 0.001, ****p < 0.0001