Fig. 1
Plaques develop with age in AppNL-F and AppNL-G-F mice. a and b) Examples of plaques detected using LCOs (green) in AppNL-F (a) and AppNL-G-F (b) hippocampus at the ages indicated. DAPI nuclear counterstain (blue). c) Median and upper quartile range for Aβ pathology scores (0–5; Supplementary Fig.1). Sample sizes (animals) are indicated within the bars. Sections (30 μm thick) were labelled with LCOs and scored blind to experimental group. While there was a significant effect of age (p < 0·0001) and there were no significant differences between the sexes at any given age. (Genotype effects were not assessed by age, as the progression of plaques is known to be slower in AppNL-F than AppNL-G-F.) Note that, for each animal, the score is the average of three sections, giving one value per animal which may not be an integer