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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia

Fig. 5

Microgliosis occurs at an earlier plaque pathology stage in AppNL-F than AppNL-G-F mice. A) Example of a ramified (left) and amoeboid (right) microglial cell in CA1 of 9-month-old AppNL-G-F mice. Scale bar for both images shown on right image. B) Densities of IBA1+ microglia in male (panel i) and female (panel ii). A generalised linear mixed model, with comparisons of Age × Genotype within Sex was followed by a sequential Sidak post hoc analysis. ** p < 0.01; *** p < 0.001; **** p < 0.0001 with respect to age- and sex-matched wild type (Males: 9-month-old p = 0·00048; 18-month-old p = 2·2 × 10−6; 24-month-old AppNL-F p = 0·016, AppNL-G-F F p = 1·4 × 10−5; Females; 9-month-old p = 0·00031; 24-month-old p = 0·0086). Data plotted as mean ± SEM. Sample sizes (animals) are indicated within the bars. C) Sigmoidal fit to microglial density plotted against corresponding pathology score for an individual animal. Genotype is indicated by colour (red: AppNL-G-F; blue: AppNL-F); both male and female data are included

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