Fig. 8
Summary timelines of phenotypes in APP knock-in and transgenic mice. Timelines for indicated phenotypes in AppNL-F (left), AppNL-G-F (centre) and TASTPM transgenic mice (right). AppNL-F and AppNL-G-F data are all included in the current publication. TASTPM data were published in Matarin et al., 2014; Cummings et al., 2015; and Medawar et al., 2019 (a preliminary comparison was presented in Joel et al., 2018). Note the phenotypic development in relation to plaque deposition within each mouse model and across the three models. Magnitudes of change across different phenotypes are not necessarily proportional; however, within any given phenotype, magnitudes of change across genotypes are proportional. Microgliosis refers to densities of IBA1+ microglia. Probability of glutamate release is based on paired-pulse ratio data. Spontaneous and miniature EPSCs reflect changes in frequency