Fig. 3
From: Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma
WldS+/+ Prevents Dendritic Pruning of αON-S RGCs During IOP Elevation. A Reconstructed dendritic arbors of WT αON-S RGCs from Ctrl and microbead-injected eyes. B Sholl analysis shows IOP elevation reduced the number of dendritic intersections between 90 and 100 μm from soma (p ≤ 0.05) of WT αON-S RGCs. C Similarly, IOP elevation significantly decreased the number of branching points in WT αON-S RGC dendrites (p < 0.001). For WT αON-S RGCs, IOP elevation did not significantly affect dendritic field area (p = 0.14) or soma area (p = 0.25). D Reconstructed dendritic arbors of WldS+/+ αON-S RGCs from Ctrl and microbead-injected eyes. E Sholl analysis shows IOP elevation does not significantly affect the number of dendritic crossings in WldS+/+ αON-S RGC (p ≥ 0.37). F Dendritic branching (p = 0.51), field area (p = 0.30), and soma area (p = 0.79) of WldS+/+ αON-S RGCs remain intact during IOP elevation. Statistics: Two-way repeated measures ANOVA, Bonferroni post hoc (B, E); Student’s t-test (C, F). Scale bars = 50 μm. Data presented as mean ± SEM