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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma

Fig. 4

WldS+/+ Protects αON-S RGC Light Responses and RMP During Glaucoma. A Mean light-evoked spike rate histograms (300 ms bin width) of αON-S RGCs from Ctrl and microbead eyes of WT mice. B IOP elevation reduced light-evoked average spike rate (− 23% 40.8 ± 9 vs. 52.7 ± 5 spikes/s, p = 0.002), peak spike rate (− 30%, 58.3 ± 11.5 vs. 83.1 ± 6.5 spikes/s, p = 0.0003), integrated response (− 31%, 111.7 ± 26.5 vs. 162 ± 15.6 spikes, p = 0.0001), and C depolarized RMP (− 58.3 ± 1.2 vs. -61.2 ± 0.5 mV, p = 0.02). D Mean light-driven spike rate histograms of αON-S RGCs from WldS+/+ Ctrl and microbead eyes. E IOP elevation does not affect light-evoked mean firing rate (p = 0.55), peak spike rate (p = 0.84), integrated response (p = 0.72), or F RMP (p = 0.24) of WldS+/+ αON-S RGCs. Statistics: Mann-Whitney test (B, C, F); Student’s t-test (E). Data = mean ± SEM

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