Fig. 6
From: Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma
WldS+/+ Does Not Prevent IOP-Induced Dendritic Degeneration in αOFF-S RGCs A Example tracings of WT αOFF-S RGC dendritic arbors from Ctrl and microbead-injected eyes. B Sholl analysis shows the number of dendritic crossings of WT αOFF-S RGC is unaffected by IOP elevation (p ≥ 0.79). C IOP elevation significantly reduced the number of dendritic branching points in WT αOFF-S RGC (43 ± 1.9 vs. 56.4 ± 2.3 branch points, p = 0.003), but dendritic field area (p = 0.20) and soma area (p = 0.63) remain intact. D Representative reconstructions of WldS+/+ αOFF-S RGC dendritic arbors from Ctrl and microbead-injected eyes. E IOP elevation does not affect the number of dendritic intersections in WldS+/+ αOFF-S RGCs (p > 0.99). F IOP elevation reduced the number of dendritic branching points in WldS+/+ αOFF-S RGCs (38 ± 2.2 vs. 46 ± 2.4 branch points, p = 0.03), but elevating IOP did not affect dendritic field area (p = 0.62) or soma area (p = 0.90). Statistics: Two-Way Repeated Measures ANOVA, Bonferroni post hoc (B, E); Student’s t-test (C, F); Mann-Whitney test (F, soma area). Scale bars = 50 μm. Data = mean ± SEM