Fig. 7
From: Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma
WldS+/+ Does Not Protect Light-Evoked Responses of αOFF-S RGCs During IOP Elevation. A Average light-driven spike rate histograms (300 ms bin width) of WT αOFF-S RGCs from Ctrl and microbead eyes. B IOP elevation significantly reduced light-evoked integrated response of WT αOFF-S RGCs (− 20%, − 66.1 ± 13.5 vs. 82.8 ± 9 spikes, p = 0.011), C but RMP of αOFF-S RGCs from Ctrl and microbead-injected eyes is similar (p = 0.55). D Mean light-evoked spike rate histograms of WldS+/+ αOFF-S RGCs from Ctrl and microbead eyes. E IOP elevation significantly decreased the peak response to light offset in WldS+/+ αOFF-S RGCs (− 42%, 40 ± 5.7 vs. 69 ± 7.5 spikes/s, p = 0.01), and modestly reduced the mean (p = 0.12) and integrated (p = 0.09) response to light offset. F RMP is similar for WldS+/+ αOFF-S RGCs from Ctrl and microbead-injected eyes (p = 0.13). Statistics: Student’s t-test (B, C, E, F); Mann-Whitney test (E, peak spike rate). Data = mean ± SEM