Fig. 3

CTE/FTLD-MAPT TMT WGCNA modules map to AD-TMT modules and demonstrate strong overlap at the individual protein expression level. A. WGCNA module membership was compared between the CTE/FTD TMT proteomic data and recently publish AD TMT dataset. Although module color varied, many of the modules were well preserved between the two datasets. log10 (p-values) are shown in the red and blue boxes which highlight the intersection of modules with statistically significant overlap (red) or depletion (blue). B. Correlation at the protein level of log2 expression values demonstrated strong overlap between both AD and CTE IV (left) as well as AD and FTD-MAP (right). Individual proteins are plotted in their respective module colors. Correlation constants and p-values are designated within each plot. C. We calculated synthetic eigengenes within the CTE dataset for proteins from the AD dataset. 5 modules identified in Fig. 3B are shown. The vertical line on each box plot separates the two data sets (CTE eigengenes on the left, AD synthetic eigengenes on the right). Control or disease state is listed on the x-axis. Kruskal-Wallis p-values are shown for each group