Fig. 1
From: Pharmacological rescue of cognitive function in a mouse model of chemobrain
Lithium pretreatment rescues paclitaxel-induced short-term memory impairment. (A) Schematic illustration of paclitaxel and lithium injection scheme, followed by behavioral tasks (OFE = open-field exploration, DOR = displaced object recognition, D = displaced, F = familiar). (B-E) Locomotor activity and anxiety were similar across all groups at 4 and 22 DPI. One-way ANOVA, p > 0.3 for all comparisons. (F-I) Paclitaxel treatment impaired short-term memory acquisition, which was rescued by lithium pre-treatment (t-test, adjusted for multiple comparisons). 5 DPI: (F) p > 0.2 for all groups (G) p = 0.004 for Saline/Veh, p = 0.003 for LiCl/Veh, p = 0.41 for Saline/PTX, p = 0.003 for LiCl/PTX. 23 DPI: (H) p > 0.3 for all groups. (I) p = 0.047 for Saline/Veh, p = 0.005 for LiCl/Veh, p = 0.70 for Saline/PTX, p < 0.0001 for LiCl/PTX. N = 8–17 mice per group