Fig. 2

Lithium posttreatment within a limited window reverses paclitaxel-induced short-term memory impairment. (A) Schematic illustration of paclitaxel and lithium injection scheme, followed by behavioral tasks (OFE = open-field exploration, DOR = displaced object recognition, D = displaced, F = familiar). (B-E) Lithium posttreatment within 10 days of paclitaxel injection rescued short-term memory impairment (t-test, adjusted for multiple comparisons). 5 DPI: (B) p > 0.3 for all groups, (C) p = 0.001 for group 1, p = 0.86 for group 2, p = 0.86 for group 3. 23 DPI: (D) p > 0.3 for all groups, (E) p = 0.025 for group 1, p = 0.003 for group 2, p = 0.99 for group 3. (F-G): paired t-test. (G) p = 0.015 for group 2, p > 0.05 for all other groups. N = 6–7 mice per group