Fig. 3
From: Pharmacological rescue of cognitive function in a mouse model of chemobrain
Lithium pretreatment rescues paclitaxel-induced deficits in granule cell morphology. (A) Diagram showing the region where the cells were imaged. (B) Representative traces of granule cells from each group, scale bar shown is 50 μm. (C-D). Paclitaxel treatment reduced granule cell complexity, which could be rescued by lithium pretreatment (C) Repeated measures two-way ANOVA, Distance: F(3.582, 211.4) = 121.0, p < 0.0001, Treatment: F [3, 59]=7.653, p = 0.0002, Distance x Treatment: F(60, 1180) =2.154, p < 0.0001. Dunnet’s multiple comparisons test between Saline/Veh and Saline/PTX: p < 0.05 between 20 to 90 μm from the soma. (D) One-way ANOVA: p < 0.0001, Tukey posthoc test: p = 0.0003 for Saline/Veh vs. Saline/PTX, p = 0.015 for Saline/PTX vs. LiCl/PTX, p = 0.42 for Saline/Veh vs. LiCl/PTX. N = 3–4 neurons per mouse, 4–6 mice per group