Fig. 5From: Pharmacological rescue of cognitive function in a mouse model of chemobrainPKCα expression and activity increase primarily in the cortex. (A-B) At 30 DPI, PKCα was upregulated in the cortex, but not in the hippocampus, of the Saline/PTX group. (A) One-way ANOVA, p = 0.57. (B) p = 0.0059, Tukey post-hoc test: p = 0.026 for Saline/Veh vs. Saline/PTX, p = 0.042 for Saline/PTX vs. LiCl/PTX, p = 0.99 for Saline/Veh vs. LiCl/PTX. (C-F) PKCα was upregulated both in the hippocampus and cortex after a single paclitaxel injection. (C) Two-tailed t-test, p = 0.03, (D) p = 0.0096, (E) p = 0.58, (F) p = 0.068. N = 4–10 mice per group for chronic expression. N = 4–8 per group for acute expressionBack to article page