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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Pharmacological rescue of cognitive function in a mouse model of chemobrain

Fig. 6

PKC inhibitor chelerythrine pretreatment rescues paclitaxel-induced short-term memory impairment. (A) Schematic illustration of paclitaxel and chelerythrine injection, followed by behavioral tasks (OF = open-field exploration, DOR = displaced object recognition, D = displaced, F = familiar, Chel = chelerythrine). (B-E) Locomotor activity and anxiety were similar across all groups at 4 and 22 DPI. One-way ANOVA, p > 0.3 for all comparisons. (F-I) Chelerythrine pretreatment rescued paclitaxel-induced cognitive impairment. (F-I): t-test, adjusted for multiple comparisons. 5 DPI: (F) p > 0.3 for all groups, (G) p = 0.031 for Veh/Veh, p = 0.0047 for Chel/Veh, p = 0.75 for Veh/PTX, p = 0.0047 for Chel/PTX. 23 DPI: (H) p > 0.15 for all groups. (I) p = 0.029 for Veh/Veh, p = 0.0008 for Chel/Veh, p = 0.55 for Veh/PTX, p = 0.022 for Chel/PTX. N = 5–8 mice per group

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