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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Fig. 2

SAP-enriched primary lysosomes are accumulated in the 1st layer of DNs. Fixed brain sections from 6-month-old APPNL-G-F mice were co-labelled with antibodies specific to LAMP1 and LAMP2 (A), LAMP1 and SAPs (B), LAMP1 and SAP-C (C), SAPs and SAP-C (D), LAMP1 and ATG9A (E), ATG9A and SAP-C (F), LAMP1 and RTN3 (G), SAP-C and RAB7 (H), and LAMP1 and ubiquitin (I). LAMP1 and SAP-C were largely co-localized with each other in the 1st layer of DNs, which was labeled by ATG9A, and surrounded by a 2nd layer marker, RTN3, and the 3rd layer markers RAB7 and ubiquitin. Scale bar is shown at the bottom right

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