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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Fig. 3

Differential association of lysosomal proteins in DNs during plaque growth in APPNL-G-F mouse brains. Fixed brain sections from 1.5- (A, F and K), 3- (B, G and L), 6- (C, H and M), 9- (D, I and N) and 15- (E, J and O) month (m)-old APPNL-G-F mice were double-labeled with antibodies against ß-amyloid plaque (6E10) and LAMP1 (A-E), SAP-C and PSAP (F-J), and SAP-C and ATG9A (K-O). Both LAMP1+ and SAP-C+ DNs appeared at early stages of plaque formation, when ATG9A also labelled DNs. The intensities of LAMP1- and SAP-C-labeled DNs were gradually reduced from 6 m to 15 m. At 15 m, residual LAMP1 staining was apparent and very little SAP-C+-DNs existed at this age. ATG9A-labeled DNs were abundant at 15 m

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