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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Fig. 4

Labeling DNs by SAP-C and SAPs at early stage of AD progression in human postmortem brain. A-B Fixed brain section from hippocampus area of Braak & Braak stages I, II and VI AD patients were DAB stained with either  SAP-C (A) or SAPs (B) antibodies. Amyloid plaques were labeled by thioflavin (Thio-S) staining. SAP-C+-DNs were marked by dotted circles while SAPs+-DNs were indicated by white arrowheads. C-D AD brain samples were also examined by immunofluorescent staining with SAP-C (C) or SAPs (D) to mark these DNs. Ubiquitin antibody marked outer layer 3 DNs while Thio-S was used to mark amyloid plaques. Scale bar shown at the bottom of each panel. SAPs antibodies labeled DNs in Braak & Braak stages I and II samples, but much fewer in Braak & Braak stage VI samples

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Molecular Neurodegeneration

ISSN: 1750-1326