Fig. 1
From: SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease
Multiple sites of lysine monomethylation detected on soluble Tau from human entorhinal cortex tissue. A Sequence coverage of the human 2N4R Tau isoform (UniProtKB-P10636–8). Dashed line: N-terminal repeats N1 and N2, solid line: microtubule binding domain (MTBR). Font color in blue: sequence covered by peptides obtained by both AspN and trypsin digestion, red: sequence covered exclusively by AspN-derived peptides, green: sequence covered exclusively by trypsin-derived peptides, black lower case: sequence not recovered by MS. B Summary of lysine monomethylation sites identified by LC-MS/MS on 2N4R Tau. C Prevalence of each monomethyl-modified lysine across the MS data set, black: found, white: not found