Fig. 3
From: Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis
Mouse plasma EVs from two ALS mouse models have peculiar size distribution, similarly to human ALS plasma EVs. a, e Representative average curve of size distribution of SOD1G93A mice at 10 and 16 weeks and of TDP-43Q331K mice at 10 months and age-matched controls. b Box-plot showing the number of particles per mL in plasma of SOD1G93A mice at 10 and 16 weeks, compared to controls. One-way ANOVA, p = 0.029; *p = 0.028 between SOD1G93A 16 weeks and controls by Tukey’s multiple comparisons test. c Box-plots showing the number of particles per mL below 130 nm of SOD1G93A EVs at 10 and 16 weeks compared to controls; one-way ANOVA, p = 0.069. d Box-plot showing the mean diameter of plasma EVs of SOD1G93A EVs at 10 and 16 weeks compared to controls. One-way ANOVA, p = 0.57. f Box-plot showing the number of particles per mL in plasma of TDP-43Q331K mice at 10 months compared to controls. Student t-test, **p = 0.0063. g Box-plots showing the number of particles per mL below 130 nm of TDP-43Q331K mice at 10 months compared to controls. Student t-test, *p = 0.012. h Box-plot showing the mean diameter of plasma EVs of TDP-43Q331K EVs at 10 months compared to controls. Student t-test, *p = 0.039