Fig. 4
From: Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis
HSP90, but not PPIA, shows specific enrichment in relation to the disease in human and mouse plasma EVs. a, b Representative immunoblotting for HSP90 (a), and PPIA (b) and relative Red Ponceau in human EV samples. IS means internal standard. c Box-plot showing the levels of HSP90 in the plasma EVs of ALS, HC, MD and SBMA. One-way ANOVA, p < 0.0001; ***p = 0.0003 ALS versus HC and **p = 0.0047 ALS versus SBMA by Dunnett’s multiple comparisons test. d Box-plot showing the levels of PPIA in the plasma EVs of ALS, HC, MD and SBMA. one-way ANOVA, p = 0.22. e Box-plot showing the levels of HSP90 in SOD1G93A plasma EVs at 10 and 16 weeks of age compared to controls. One-way ANOVA, p = 0.29. f Box-plot showing the levels of HSP90 in TDP-43Q331K plasma EVs at 10 months of age compared to controls. Student t-test, *p = 0.037. c-f A.U.: arbitrary units