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Table 1 Characteristics of ALS patients and controls

From: Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Characteristics ALS Slow-ALS1 Fast-ALS2 HC3 MD4 SBMA5
N. 106 60 46 36 28 32
Age at sampling, median (range) 67 (42–89) 65 (42–81) 70 (48–89) 61 (24–78) 53 (25–78) 62 (46–83)
Sex (male/female) 64/42 41/19 23/23 15/21 13/15 32/0
Site of disease onset (bulbar/spinal) 28/77 7/52 21/25
ALSFRS-R at sampling, median (range) 34 (2–47) 37 (4–35) 27 (2–41)
ΔALSFRS-R6, median (range) 0.86 (0.05–9.0) 0.54 (0.05–0.95) 1.48 (0.97–9)
Disease duration7, median months (range) 14 (3–179) 15 (3–179) 13 (3–46)
Gene mutations
(SOD1/C9orf72/TDP-43/FUS)
10/106 (4/5/1/0) 6/60 (3/2/1/0) 4/46 (1/3/0/0)
  1. 1Slow-ALS: ΔALSFRS-R < 0.96; 2Fast-ALS: ΔALSFRS-R > 0.96; 3HC Healthy control; 4MD muscular dystrophy; 5SBMA spinal and bulbar muscular atrophy; 6ΔALSFRS-R: 48– ALSFRS-R score at the plasma collection/time between symptom onset and sampling; 7Disease duration: from symptom onset to plasma collection