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Table 1 PGRN cleavage by lysosomal proteases in vitro

From: Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

  1. Summary of whether the enzymes tested could cleave progranulin (PGRN) or not along with the potential compartment it may cleave PGRN depending on the pH it processed progranulin in vitro. En, endosomes; Ly, lysosomes; Ex, extracellular