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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

Fig. 2

Protein samples are analyzed by pre-MS sample processing, MS data acquisition and post-MS bioinformatic data processing. Protein quantification can be achieved by label-free methods, such as spectral counting (SC), extracted ion current (XIC), and data-independent acquisition (DIA), or by isotope-labeling methods, such as SILAC and TMT. In addition, MS may also be operated to analyze targeted proteins/peptides by multiple reaction monitoring (MRM) or parallel reaction monitoring (PRM)

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Molecular Neurodegeneration

ISSN: 1750-1326