Fig. 4
From: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
A meta-analysis integrating 7 deep AD datasets and identifying 12,017 proteins. In each dataset, the p value for control-AD comparison is derived by one-tailed t-test. The p values are combined by the Fisher’s method, followed by multiple-hypothesis correction using the Benjamini-Hochberg FDR procedure. A total of 2,698 DE proteins are accepted with the FDR cutoff of 1 %. Compared to 167 reported AD genes and risk loci, 35 are overlapped with the protein DE list. Based on cell type specific genes, the DE list contains 638 genes/proteins specific to all five major cell types in the brain