Fig. 5
From: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
The equilibrium model of deleterious and protective factors during AD disease progression. Among the biological processes and cellular pathways activated at the asymptomatic stage of AD, some may exert protective roles. However, with exacerbation of the harmful insults during disease progression, the protective effect is exhausted. The resulting imbalance leads to neuronal degeneration and the onset of clinical symptoms. The pathway information is extracted from current AD proteomic studies [74, 75, 78, 161]