SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Table 1 List and characteristics of patient-derived neurons used for the genome-wide investigation of SRSF1 depletion by RNA-seq

Patient cell lines	Ethnicity	Gender	Cell type	Age at biopsy sample collection (years)
H1 (3050)	Caucasian	Male	Healthy control	68
H2 (155)	Caucasian	Male	Healthy control	40
H3 (154)	Caucasian	Female	Healthy control	55
C9–1 (78)	Caucasian	Male	C9ORF72-ALS	66
C9–2 (183)	Caucasian	Male	C9ORF72-ALS	49
C9–3 (201)	Caucasian	Female	C9ORF72-ALS	66
CS14	Caucasian	Female	Healthy control	30–35
MIFF1	Caucasian	Male	Healthy control	Unknown
ALS-28	Caucasian	Male	C9ORF72-ALS	47
ALS-29	Caucasian	Male	C9ORF72-ALS	47
ALS-29 ISO	Caucasian	Male	Isogenic ALS-29 line lacking the repeat expansion	47

ISSN: 1750-1326