Cellular and pathological heterogeneity of primary tauopathies

Table 2 A list of transgenic mouse models showing tau lesions in non-neuronal cell types

Name (if applicable)	Human tau isoform	Mutation (if applicable)	Promoter	Type of p-tau + cells	Ref.
TG23	0N3R	WT	HMG-CR	Neuron, astro	[173]
-	2N4R	p.G272V	mPrP-tTA	Neuron, olig	[174]
JNPL3	0N4R	p.P301L	mPrP	Neuron, astro, olig	[175, 176]
rTg4510	0N4R	p.P301L	CaMKII-tTA	Neuron, olig	[177, 178]
Tα1-3RT tau Tg	0N3R,1N3R, 2N3R	WT	mTα1α-tubulin	Astro, olig	[179]
T-279	2N4R	p.N279K	hTau	Neuron, astro	[180]
GFAP/tauWT	1N4R	WT	GFAP	Astro	[115, 181]
GFAP/tauP301L	1N4R	p.P301L	GFAP	Astro	[115]
-	1N4R	WT or p.P301L	mCNP	Olig	[182]

Abbreviations: astro astrocyte; CaMKII calcium/calmodulin kinase IIα promoter; GFAP Glial fibrillary acidic protein; HMG-CR HMG-CoA reductase; hTau human tau; mCNP mouse 2', 3'-cyclic nucleotide 3'-phosphodiesterase; mPrP mouse prion; olig oligodendrocyte; tTA tetracycline-responsive transactivator; WT wild-type

ISSN: 1750-1326