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Table 3  A list of sporadic mouse models developed by injection of tau seeding materials

From: Cellular and pathological heterogeneity of primary tauopathies

Genetic background Injection sites & length Injection materials Type ofp-tau + cells Type of tau lesions Brain areas with lesions Ref.
ALZ17 (tg mice expressing WT human tau) (3-mo) HPC, CTX (for 6–15 months) AD brain homogenates Neuron, olig NFTs, NTs, dystrophic neurites, coiled bodies HPC and several connected areas (e.g., fim, amyg, thalamus, etc.); PiD-induced lesions were limited to injection sites [26]
TD brain homogenates Neuron, olig NFTs, NTs, coiled bodies
PiD brain homogenates Neuron, olig Short and thick NTs, coiled bodies
PSP brain homogenates Neuron, olig, astro Nerve cell body inclusions, NTs, coiled bodies, tufted astrocytes
CBD brain homogenates Neuron, olig, astro Nerve cell body inclusions, NTs, coiled bodies, astrocytic plaques
AGD brain homogenates Neuron, olig, astro Argyrophilic grains, NFTs, coiled bodies, non-fibrillar astrocytic pathology
Non-tg mice (C57BL/6; 2-3-mo) HPC, CTX (for 1–9 months) Sark-insoluble AD-tau Neuron Pretangles HPC, CTX [28]
Sark-insoluble PSP-tau Neuron, olig, astro Mature tangles, coiled bodies, tufted astrocytes, astrocytic plaques HPC, CTX, fim, CC
Sark-insoluble CBD-tau Neuron, olig, astro Mature tangles, coiled bodies, astrocytic plaques HPC, CTX, fim, CC
Non-tg mice (C57BL/6; 3–7 mo) Ventricles, HPC (for 3–7 months) Sark-insoluble ARTAG-tau Neuron, olig, astro p-tau + neurons/oligo/astro HPC, fim, CC, fornix [184]
Non-tg mice (C57BL/6; 3- 12-mo) HPC, CC, and CPu (for 4–7 months) Sark-insoluble GGT-tau Neuron, olig Pretangles, NTs, coiled bodies HPC, fim, CC, CPu [114]
TauKDncre;fl/fl(specific knockdown of neuronal mouse tau; age n/d) HPC, CTX (for 3–6 months) Sark-insoluble AD-tau Little to no p-tau + cells No tau lesions No tau lesions [185]
Sark-insoluble PSP-tau Neuron, olig, astro NTs, coiled bodies, tufted astrocytes HPC, fim, CC
Sark-insoluble CBD-tau Neuron, olig, astro NTs, coiled bodies, astrocytic plaques, HPC, fim, CC
6hTau (expressing all six human tau isoforms; no endogenous mouse tau; 3-5-mo) HPC, CTX (for 1–9 months) Sark-insoluble AD-tau Neuron NFTs, NTs HPC, CTX [186]
Sark-insoluble PSP-tau Neuron, olig, astro NFTs, NTs, p-tau + oligodendrocytes, tufted astrocytes HPC, CTX, fim
Sark-insoluble CBD-tau Neuron, olig, astro NFTs, NTs, p-tau + oligodendrocytes, astrocytic plaques HPC, CTX, fim, CC
Sark-insoluble PiD-tau Neuron, olig NFTs, NTs, p-tau + oligodendrocytes HPC, CTX, fim
  1. Abbreviation: AD Alzheimer’s disease; AGD argyrophilic grain disease; amyg amygdala; ARTAG aging-related tau astrogliopathy; astro astrocyte; CBD corticobasal degeneration; CC corpus callosum; CPu caudate/putamen; CTX cortex; DG dentate gyrus; fim fimbria; GGT globular glial tauopathy; HPC hippocampus; mo month-old; n/d not described; NFT neurofibrillary tangles; NT neuropil thread; olig oligodendrocyte; PiD Pick’s disease; PSP progressive supranuclear palsy; sark sarkosyl; TD tangle-only dementia; tg transgenic