Fig. 3From: Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulationhFUS transgene corrects abnormal cytoplasmic accumulation of FUS in Fus∆NLS motor neurons. A: FUS immunohistochemistry in the spinal cord ventral horn at 22 months of age of mice with the indicated genotypes labelled as in previous figures. Note that diffuse FUS cytoplasmic staining, obvious in FusΔNLS/+ mice, is rescued by the hFUS transgene. Scale bar: 50 μm. B-E: Double immunostaining for the motorneuronal marker ChAT (red), nuclei (blue) and either total FUS (B), C-terminal FUS (C), mouse FUS (D) or ADMA-FUS (D) in the spinal cord ventral horn at 22 months of age. Scale bar: 20 μmBack to article page