Fig. 4
From: Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
hFUS transgene downregulates endogenous Fus mRNA levels in the spinal cord. A-D: RT-qPCR results for total (human + mouse) mRNA encoding FUS (A), endogenous mouse Fus mRNA (B), human FUS transgene (C) and mutant Fus mRNA carrying the ∆NLS mutation (D) in spinal cord at 1 month (left) or 22 months (right) of age. Note that the hFUS transgene decreases expression of endogenous Fus gene and leads to decreased expression of mutant Fus mRNA at 1 and 22 months of age in the spinal cord. N = 4–8. *, p < 0.05, **p < 0.01, **p < 0.001 vs. Fus+/+, #, p < 0.05, ###, p < 0.001 vs. indicated genotype by ANOVA followed by Tukey