Fig. 4
From: Functional microRNA targetome undergoes degeneration-induced shift in the retina
Network analysis of the top 20 DR and PD retinal AGO2-bound miRNAs. (A) Schematic of the analysis conducted for the top 20 DR and PD AGO2-bound miRNAs. (B) Pie chart showing the AGO2-bound miRnome of DR and PD retinas (see also Table S3A). The top 20 miRNAs are individually listed, with miR-124-3p comprising approximately 75 and 81% of the miRnome respectively. (C) Target network analysis for the top 20 AGO2-bound miRNAs was performed with miRNet using all AGO2-bound mRNAs as putative target set (see also Table S3B). The results for 14 miRNA are shown, the remaining six miRNAs were not annotated in the system. Each miRNA is represented by a square box, with its size indicating the number of interactions. Black dots represent interacting mRNAs connected by lines to the respective miRNA. (D) Gene ontology (GO) analysis was performed using the most abundant AGO2-bound mRNA transcripts identified in DR and PD retinas to view the most enriched biological processes involved (P < 0.05)