Skip to main content
Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

Fig. 5

Schematic overview of the cellular mechanisms and processes modulating the KEAP1-NRF2 system. Activators (upper panels) and inhibitors (bottom panels) tightly modulate KEAP1-NRF2 activity at the level of DNA, RNA, and protein: transcriptional regulation, post-transcriptional regulation, protein stability, availability of binding partners, and post-translational regulation are involved. Red arrows indicate the activating effect, while blue bars indicate an inhibitory effect

Back to article page