Fig. 2

Level 1 comparison of ATAC-seq data from neuronal vs non-neuronal nuclei. a MA plot showing differential ATAC-seq sites between neuronal (blue) vs. non-neuronal regions (red). Red dots represent ATAC-seq peaks that are significantly different between groups (FDR q < 0.05). b ATAC-seq data around non-neuronal-specific genes SLC25A18 (upper panel) and ACSBG1 (lower panel). Boxes highlight peaks that are more accessible in neuronal (red) or non-neuronal (blue) nuclei. c ATAC-seq data around neuron-specific genes MEF2C (upper panel) and SLA (lower panel). All regions indicate hg19 coordinates. d Venn diagram of ATAC-seq peaks detected in whole tissue, sorted neuron and sorted non-neuron nuclei from 6 donor-matching samples