Fig. 5

Differential LOAD specific ATAC-seq peaks around LOAD-GWAS regions. Screenshots of ATAC-seq data around a PTK2B, CLU, b APOE, and c IQCK loci. Box plots show ATAC-seq read counts for individual ATAC-seq peaks (blue frames highlight significant differential peaks for cases vs. controls, gray frames show control peaks that are not differential between cases and controls). Box plots are color coded for non-neuronal (blue) neuronal (red), female (no fill), and male (gray fill). All tracks show hg19 coordinates and all y-axes on tracks range from 0 to 250. For box plots, the line within each box represents the median, and the top and bottom borders of the box represent the 25th and 75th percentiles, respectively. The top and bottom whiskers of the box plots represent the 75th percentile plus 1.5 times the interquartile range and the 25th percentile minus 1.5 times the interquartile range, respectively