Skip to main content
Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Fig. 2

Decreased m6A-related regulator proteins in AD brains. (A-B) Representative immunohistochemical staining (A) and quantifications (B) of METTL3, METTL14, FTO or YTHDF1 in hippocampus (Left, Hipp) and cortex (Right, CTX) from human AD and age-matched control cases (n = 6 cases per group). (C-D) Representative immunoblot (C) of proteins of m6A regulators in frontal cortical tissues from human AD and age-matched control cases and quantitative analysis (D) revealed significantly decreased protein levels of many of these regulators in AD brains (n = 6 cases per group). (E-F) Representative immunoblot (E) of proteins of m6A regulators in middle temporal gyrus tissues from human MCI and age-matched control cases and quantitative analysis (F) revealed significantly decreased METTL3 protein levels in MCI brains (n = 5–6 cases per group). GAPDH was probed as an internal loading control. (Data are means±SEM, *p < 0.05, **p < 0.01, ***p < 0.001; (B, D, F) unpaired student’s t-test)

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326