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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Fig. 4

METTL3 knockdown in the hippocampus caused cognitive/memory deficits. (A, B) showed percent of spontaneous alternations (A) and total entries (B) in the Y-maze assay for shMettl3-injected WT mice and shCtrl-injected mice. (C-D) The NOR task (C) was used to assess recognition memory and the OLT task (D) was used to assess the hippocampus-dependent spatial memory function in shRNA-injected mice. The preference index for each mouse was determined by dividing the amount of time spent exploring the novel (C) or displaced (D) object by the total amount of time spent exploring both objects. (E, F) Total distance traveled and time in the center in the open field (OF) test were recorded. Locomotor activity (E) and percent total time in center (F) were calculated. (n = 13 mice in shCtrl-injected group; n = 17 mice in shMettl3-injected group). (Data are means±SEM, *p < 0.05, ***p < 0.001; (A-F) unpaired student’s t-test)

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Molecular Neurodegeneration

ISSN: 1750-1326