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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Fig. 6

METTL3 knockdown in the hippocampus caused oxidative stress and aberrant cell cycle events. (A-G) Representative immunohistochemistry images of 4-HNE (A, upper), γH2AX (A, lower), CCND1 (C), CCND2 (D), CCNB1 (E) and PCNA (F) in hippocampal CA3 region in shRNA-injected mice. Quantifications showed increased immunoreactivities of above oxidative stress makers (B) and cell cycle makers (G) by METTL3 depletion in the hippocampus. (n = 4–6 mice in each group.) (Data are means±SEM, *p < 0.05, **p < 0.01, B, G unpaired student’s t-test)

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Molecular Neurodegeneration

ISSN: 1750-1326