Fig. 7

L-DL improves cognitive function in APP/ PS1 mice. a, b Levels of L-DL in the hippocampus of 6-month-old APP/PS1 and age-matched WT mice, determined by immunoblotting (a) and densiometric analysis (n = 3) (b). c, d Levels of L-DL in the hippocampus of APP/PS1 mice administered with zsGreen-L-DL, determined by immunoblotting (c) and densiometric analysis (n = 3) (d). e, f Levels of L-DL in the hippocampus of APP/PS1 mice treated with control or L-DL shRNA, determined by immunoblotting (e) and densiometric analysis (n = 3) (f). g-j APP/PS1 mice with L-DL overexpression (OE) or knockdown (KD) were subjected to behaviour assays. g, h Discrimination index for APP/PS1 mice with L-DL OE (g) or L-DL KD (h) in novel object recognition task (n = 15 mice per group). i, j Time spending in the novel arm for APP/PS1 mice with L-DL OE (i) or L-DL KD (j) in Y maze (n = 15 mice per group). Statistical analysis was performed using two-tailed Student’s t-test; * P < 0.05, ** P < 0.01, *** P < 0.001; error bars denote SEM