Fig. 2
From: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
αSyn PFF-Injected dTg Mice Exhibit Exacerbated αSyn Pathology Compared to αSyn PFF-Injected M20 Mice. A Representative IHC images of hippocampus and cortex from M20 and dTg mice (10-month-old; 4 m.p.i.) that were injected with αSyn PFFs, and stained with antibodies specific for αSyn phosphorylated on Ser129 (81A), aggregated αSyn (5G4), and p62/sequestrasome-1. B Representative images demonstrating the lack of pathological αSyn inclusions in PBS-injected dTg mice (10-month-old; 4 m.p.i.). C Semi-quantitative analysis comparing 81A and p62-positive inclusions, or normalized quantitative analysis of OD of 5G4 IRA, between M20 and dTg mice injected with αSyn PFFs. Two-Way ANOVA followed by Holm-Sidak’s multiple comparisons test (n = 8, 12; 8,11). Data are presented as mean +/− SEM. Scale bars: (A) 50 μm; (B) 200 μm