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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

Fig. 5

The Presence of Aβ and αSyn Pathology Induces More Severe Astrocytic Activation. A Representative images showing IHC using antibodies specific for GFAP to compare nTg, M20, L85, and dTg mice injected with PBS or αSyn PFFs at 8 (2 m.p.i.) and 10 months (4 m.p.i.) of age as indicated, and the corresponding heat map depicting regional GFAP percent positivity. The level of astrocytic activation is illustrated by the color change from blue (minimum of GFAP measured percent positivity) to orange (maximum measured GFAP percent positivity). Gray indicates regions were not quantified during this study. B Quantitation of GFAP percent positivity compares the intensity of activated astrocytes between the retrosplenial cortex, CA1 of the hippocampus, and the entorhinal cortex within each cohort. Two-Way ANOVA followed by Holm-Sidak’s multiple comparisons test was used for statistical analysis (n = 8,8,13; 6,8,12; 8,8,10; 6,8,11). Data are presented as mean +/− SEM. Scale bar: 1000 μm

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