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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

Fig. 3

hiPSC-astrocytes recapitulate human morphological subtypes and retain human specific features within the mouse brain. (a-j) Representative images of RFP+ (white) interlaminar (a-c), varicose-projection (d-e), protoplasmic (f-g) and fibrous astrocytes (h-j) in the brain of WT mice five months after transplantation. Scale bars: 25 μm. (k) Histogram showing the percentage of RFP+ cells of each astrocyte subtype on the mouse brain (n = 14 mice). Data are represented as mean ± SEM. (l) Representative image showing mouse (green, arrows) and hiPSC-astrocytes (red) on a chimeric mouse brain five months after transplantation. Scale bar: 25 μm. (m) Histogram plotting the size of hiPSC-derived astrocytes vs. mouse astrocytes on the host brain (n = 12 mice). Data are represented as mean ± SEM, Student’s t test: ****p < 0.0001

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