Fig. 6

Endogenous mouse astrocytes become hypertrophic or atrophic in the chimeric AD brain. (a-l) Representative immunofluorescence images of GFAP+ mouse astrocytes (red) around amyloid-deposits (Thioflavin, green) in the cortex of chimeric AD brains. (c-l) GFAP+ mouse astrocytes (red) show hypertrophic (d-e, i-j), quiescent (f, k) and atrophic (g, l) morphologies close to amyloid deposits. (d-g, i-l) Enlarged views of the insets in c and h, respectively. Scale bars: 50 μm in (a, b) and 25 μm in (c, h). (m) Percentage of GFAP+ mouse astrocytes showing quiescent, hypertrophic or atrophic morphologies in the cortex of chimeric AD brains (n = 9 mice). Data are represented as mean ± SEM, one-way ANOVA with Friedman test, ****p < 0.0001