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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

Fig. 7

Human astrocytes in the brain of AD patients undergo morphological changes in response to Aβ. (a-f) Representative immunohistochemistry images of GFAP+ astrocytes (brown) around amyloid-deposits (blue, dashed lines) in the cortex and hippocampus of AD patient brains. (a-d) Overviews (a, b) and enlarged views (c, d) of the insets in a, b, respectively. (c-f) GFAP+ hypertrophic (red arrows) and quiescent or atrophic (green arrows) astrocytes around amyloid-deposits. Scale bars: 25 μm in (a, b); 10 μm in (c-f). (g) Percentage of GFAP+ human astrocytes displaying quiescent, hypertrophic or atrophic morphologies in the entorhinal cortex and hippocampus of AD patient brains (n = 4 AD patients). Data are represented as mean ± SEM, one-way ANOVA with Friedman test, **p < 0.01

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