Table 1 Demographic data and αSyn_RT-QuIC results
Clinical diagnosis | Sex (Male) | Year of birth | Age at onset | Age at brushing | T1 (years) = disease duration | Clinical onset | Family history of parkinsonism or ataxia | Time to threshold | Fluorescence at time threshold | Mean intensity at PK 2.5 mg/mL (ITA-lab) | αSyn_RT-QuIC results | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ITA-lab | USA-lab | ITA-lab | USA-lab | ITA-lab | USA-lab | |||||||||
PD_1 | + | 1956 | 55 | 61 | 6 | (rest) tremor at left hand | – | 9.00 | 9.44 | 260,000 | 260,000 | 9.56 | + | + |
PD_2 | – | 1947 | 63 | 71 | 8 | rigidity right hand | – | 9.5 | 11.25 | 260,000 | 250,509 | 5.67 | + | + |
PD_3 | + | 1952 | 54 | 66 | 12 | bradykinesia and rigidity left hand | – | 10.25 | 12.44 | 171,531 | 260,000 | 5.59 | + | + |
PD_4 | – | 1959 | 50 | 59 | 9 | rigidity right hand | – | NA | NA | 14,452 | 6607 | 5.85 | – | – |
PD_5 | + | 1945 | 61 | 74 | 13 | rigidity and tremor | – | NA | NA | 14,026 | 7283 | 7.02 | – | – |
PD_6 | + | 1967 | 48 | 52 | 4 | dysautonomia | + | NA | NA | 13,370 | 13,623 | 6.41 | – | – |
PD_7 | + | 1967 | 49 | 51 | 2 | bradykinesia and tremor | – | 7.5 | 14.13 | 259,150 | 260,000 | 59.39 | + | + |
PD_8 | – | 1952 | 50 | 67 | 17 | bradykinesia and rigidity left hand | – | NA | NA | 17,385 | 8232 | 5.29 | – | – |
PD_9 | – | 1950 | 59 | 67 | 8 | rigidity | – | 11.33 | 19.5 | 121,284 | 49,958 | 12.32 | + | + |
PD_10 | + | 1961 | 53 | 58 | 5 | dysautonomia | – | 10.33 | 21.00 | 120,929 | 55,342 | 6.63 | + | + |
PD_11 | + | 1962 | 52 | 58 | 6 | rigidity and frozen shoulder | – | 8.88 | 15.08 | 169,629 | 159,598 | 8.19 | + | + |
PD_12 | – | 1947 | 69 | 72 | 3 | bradykinesia and rigidity left leg | + | 9.00 | 20.25 | 222,667 | 49,532 | 6.49 | + | + |
PD_13 | + | 1951 | 55 | 66 | 11 | bradykinesia and tremor | – | 8.00 | 20.25 | 260,000 | 35,814 | 11.58 | + | + |
MSA-P_1 | – | 1947 | 67 | 70 | 3 | dysautonomia | – | 10.67 | 14.56 | 183,784 | 215,981 | 81.11 | + | + |
MSA-P_2 | + | 1948 | 69 | 71 | 2 | parkinsonism | – | 10.25 | 20.88 | 173,619 | 56,919 | 56.09 | + | + |
MSA-P_3 | + | 1964 | 48 | 53 | 5 | RBD and later parkinsonism | – | 10.00 | 12.69 | 227,396 | 239,598 | 21.67 | + | + |
MSA-P_4 | + | 1965 | 50 | 53 | 3 | parkinsonism | – | 12.33 | 18.13 | 41,279 | 196,898 | 56.97 | + | + |
MSA-P_5 | + | 1957 | 56 | 62 | 6 | dysautonomia | – | 11.75 | 17.25 | 56,628 | 183,834 | 21.57 | + | + |
MSA-P_6 | – | 1957 | 54 | 61 | 7 | parkinsonism | – | 10.00 | 17.08 | 204,429 | 206,638 | 6.71 | + | + |
MSA-P_7 | – | 1946 | 72 | 73 | 1 | dysautonomia | – | 11.50 | 10.19 | 86,628 | 88,018 | 82.57 | + | + |
MSA-P_8 | + | 1973 | 40 | 46 | 6 | parkinsonism | – | 11.50 | 16.92 | 109,166 | 47,076 | 9.69 | + | + |
MSA-P_9 | + | 1976 | 39 | 44 | 5 | dysautonomia | – | 8.50 | 14.50 | 248,346 | 59,610 | 18.36 | + | + |
MSA-P_10 | + | 1962 | 55 | 57 | 2 | RBD and later parkinsonism | – | NA | NA | NA | NA | 7.27 | – | – |
MSA-P_11 | – | 1959 | 58 | 60 | 2 | parkinsonism | – | NA | NA | NA | NA | 6.98 | – | – |
MSA-P_12 | – | 1958 | 57 | 60 | 3 | parkinsonism | – | 9.67 | 20.75 | 147,488 | 135,777 | 42.32 | + | + |
MSA-P_13 | + | 1963 | 51 | 56 | 5 | dysautonomia | – | 10.50 | 18.67 | 218,123 | 82,606 | 10.26 | + | + |
MSA-P_14 | – | 1963 | 55 | 56 | 1 | parkinsonism | – | 10.50 | 17.63 | 160,382 | 260,000 | 18.2 | + | + |
MSA-P_15 | – | 1965 | 41 | 54 | 13 | parkinsonism | – | 9.50 | 20.33 | 213,766 | 84,203 | 5.77 | + | + |
MSA-P_16 | + | 1953 | 60 | 64 | 4 | bradykynesia parkinsonism | – | 11.00 | 22.50 | 133,273 | 148,704 | 8.24 | + | + |
MSA-P_17 | + | 1949 | 69 | 70 | 1 | parkinsonism | – | 10.63 | 19.13 | 224,756 | 235,573 | 95.5 | + | + |
MSA-P_18 | – | 1963 | 61 | 65 | 4 | parkinsonism | – | 8.33 | 20.00 | 260,000 | 30,995 | 42.27 | + | + |
MSA-P_19 | + | 1959 | 58 | 60 | 2 | parkinsonism | – | 10.33 | 16.33 | 183,011 | 50,658 | 34.47 | + | + |
MSA-P_20 | – | 1953 | 52 | 65 | 13 | parkinsonism | + | 12.75 | 12.63 | 43,645 | 57,486 | 5.85 | + | + |
MSA-C_1 | – | 1965 | 45 | 54 | 9 | cerebellar | – | NA | NA | NA | NA | 2.86 | – | – |
MSA-C_2 | + | 1947 | 70 | 72 | 2 | cerebellar | – | NA | NA | NA | NA | 3.07 | – | – |
MSA-C_3 | – | 1957 | 57 | 62 | 5 | RBD | – | NA | NA | NA | NA | 3.09 | – | – |
MSA-C_4 | + | 1971 | 47 | 48 | 1 | cerebellar | – | NA | NA | NA | NA | 3.37 | – | – |
MSA-C_5 | – | 1950 | 64 | 69 | 5 | cerebellar | – | NA | NA | NA | NA | 3.76 | – | – |
MSA-C_6 | + | 1964 | 50 | 55 | 5 | cerebellar | – | NA | NA | NA | NA | 3.86 | – | – |
MSA-C_7 | + | 1950 | 69 | 70 | 1 | cerebellar | – | NA | NA | NA | NA | 4.4 | – | + |
MSA-C_8 | + | 1965 | 51 | 55 | 4 | dysautonomia | – | NA | NA | NA | NA | 4.86 | – | – |
MSA-C_9 | – | 1948 | 67 | 70 | 3 | cerebellar | – | NA | NA | NA | NA | 4.68 | – | – |
MSA-C_10 | + | 1965 | 50 | 55 | 5 | cerebellar | – | NA | NA | NA | NA | 3.59 | – | – |
HS_1 | + | 1955 | NA | 64 | NA | NA | NA | NA | NA | NA | NA | 4.22 | – | – |
HS_2 | + | 1981 | NA | 38 | NA | NA | NA | NA | NA | NA | NA | 3.98 | – | – |
HS_3 | – | 1985 | NA | 35 | NA | NA | NA | NA | NA | NA | NA | 3.03 | – | – |
HS_4 | – | 1987 | NA | 32 | NA | NA | NA | NA | NA | NA | NA | 3.44 | – | – |
HS_5 | – | 1969 | NA | 50 | NA | NA | NA | NA | NA | NA | NA | 2.12 | – | – |
HS_6 | + | 1979 | NA | 38 | NA | NA | NA | NA | NA | NA | NA | 3.33 | – | – |
HS_7 | – | 1984 | NA | 35 | NA | NA | NA | NA | NA | NA | NA | 3.17 | – | – |
HS_8 | – | 1979 | NA | 39 | NA | NA | NA | NA | NA | NA | NA | 3.04 | – | + |
HS_9 | + | 1974 | NA | 45 | NA | NA | NA | NA | NA | NA | NA6 | 2.87 | – | – |
HS_10 | – | 1970 | NA | 49 | NA | NA | NA | NA | NA | NA | NA | 2.21 | – | – |
HS_11 | + | 1985 | NA | 34 | NA | NA | NA | NA | NA | NA | NA | 2.78 | – | – |