Table 5 Association analyses between αSyn_RT-QuIC seeding activity triggered by OM of PD and MSA-P patients and clinical or demographic parameters
Clinical/demographic parameter | αSyn_RT-QuIC seeding activity | p-value* | |
|---|---|---|---|
Positive | Negative | Â | |
Sex – n (%) |  |  | 1 |
 Male | 16 (84.21) | 3 (15.79) |  |
 Female | 11 (78.57) | 3 (21.43) |  |
Cerebellar syndrome – n (%) |  |  | 1 |
 Yes | 5 (83.33) | 1 (16.67) |  |
 No | 22 (81.48) | 5 (18.52) |  |
MRI putamen strie – n (%) |  |  | 1 |
 Yes | 9 (81.82) | 2 (18.18) |  |
 No | 18 (81.82) | 4 (18.18) |  |
MRI middle cerebellar peduncle – n (%) |  |  | 1 |
 Yes | 4 (100) | 0 (0) |  |
 No | 23 (79.31) | 6 (20.69) |  |
MRI cerebellum – n (%) |  |  | 0.58 |
 Yes | 5 (71.43) | 2 (28.57) |  |
 No | 22 (84.62) | 4 (15.38) |  |
Family history of parkinsonisms – n (%) |  |  | 1 |
 Yes | 2 (66.67) | 1 (33.33) |  |
 No | 25 (83.33) | 5 (16.67) |  |
Bradykinesia – n (%) |  |  | 0.08 |
 Yes | 26 (86.67) | 4 (13.33) |  |
 No | 1 (33.33) | 2 (66.67) |  |
Rigidity – n (%) |  |  | 0.01 |
 Yes | 26 (89.66) | 3 (10.24) |  |
 No | 1 (25.00) | 3 (75.00) |  |
Tremor – n (%) |  |  | 0.18 |
 Yes | 18 (90.00) | 2 (10.00) |  |
 No | 9 (69.23) | 4 (30.77) |  |
Postural instability – n (%) |  |  | 0.02 |
 Yes | 19 (95.00) | 1 (5.00) |  |
 No | 8 (61.54) | 5 (38.46) |  |
Gait freezing – n (%) |  |  | 0.14 |
 Yes | 2 (50.00) | 2 (50.00) |  |
 No | 25 (86.21) | 4 (13.79) |  |
RBD – n (%) |  |  | 1 |
 Yes | 11 (84.62) | 2 (15.38) |  |
 No | 16 (80.00) | 4 (20.00) |  |
Early gait ataxia (within 3 years of disease onset) – n (%) |  |  | 1 |
 Yes | 1 (100.00) | 0 (0.00) |  |
 No | 26 (81.25) | 6 (18.75) |  |
Gait ataxia – n (%) |  |  | 1 |
 Yes | 5 (83.33) | 1 (16.67) |  |
 No | 22 (81.48) | 5 (18.52) |  |
Limb ataxia – n (%) |  |  | 0.56 |
 Yes | 5 (100.00) | 0 (0.00) |  |
 No | 22 (78.57) | 6 (21.43) |  |
Cerebellar dysartria – n (%) |  |  | 0.56 |
 Yes | 6 (100.00) | 0 (0.00) |  |
 No | 21 (77.78) | 6 (22.22) |  |
Hyposmia – n (%) |  |  | 1 |
 Yes | 4 (80.00) | 1 (20.00) |  |
 No | 23 (82.14) | 5 (17.86) |  |
Autonomic failure – n (%) |  |  | 0.62 |
 Yes | 21 (84.00) | 4 (16.00) |  |
 No | 6 (75.00) | 2 (25.00) |  |
Orthostatic hypotension – n (%) |  |  | 1 |
 Yes | 14 (82.35) | 3 (17.65) |  |
 No | 13 (86.67) | 2 (13.33) |  |
Other cardiovascular dysautonomic symptoms – n (%) |  |  | 1 |
 Yes | 20 (83.33) | 4 (16.67) |  |
 No | 7 (77.78) | 2 (22.22) |  |
Urinary disfunction – n (%) |  |  | 0.29 |
 Yes | 23 (85.19) | 4 (14.81) |  |
 No | 4 (66.67) | 2 (33.33) |  |
Other dysautonomia – n (%) |  |  | 0.14 |
 Yes | 22 (88.00) | 3 (12.00) |  |
 No | 5 (62.50) | 3 (37.50) |  |
MRI atrophy – n (%) |  |  | 1 |
 Yes | 9 (81.82) | 2 (18.18) |  |
 No | 17 (80.95) | 4 (19.05) |  |
Age at brushing – mean (SD) | 61.22 (7.88) | 61.50 (7.82) | 0.94 |
Disease duration at sampling (year) – mean (SD) | 5.37 (3.55) | 7.83 (6.24) | 0.19 |
Beneficial L-DOPA response UPDRS – mean (SD) | 19.52 (10.76) | 21.67 (11.06) | 0.66 |
MDS-UPDRS-III OFF – mean (SD) | 34.48 (8.87) | 36.33 (12.40) | 0.67 |