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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

Fig. 1

The mtDNAcn is reduced in cortical brain regions in AD. (A-D) Boxplots comparing the mtDNAcn in the DLPFC (A and B), in the PCC (C), and in the CB (D) from individuals of the ROSMAP cohort with and without pathologic AD diagnosis. The used DNA extraction kit is denoted in brackets on the y axis. Wilcoxon rank-sum test was applied to calculate p values. (E) Boxplot shows the mtDNAcn in the TCX of controls, AD cases, PSP cases, and cases of pathologic aging from the Mayo study. Wilcoxon rank-sum test was applied to calculate p values. (F) Boxplot shows the mtDNAcn in the FP of controls and AD cases from the MSBB study. Wilcoxon rank-sum test was applied to calculate p values. (G) The estimated relative mtDNAcn observed in AD compared to controls is shown for each brain region and study

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Molecular Neurodegeneration

ISSN: 1750-1326