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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

Fig. 3

The mtDNAcn is associated with cognitive function independent of brain pathologies. (A) Forest plot shows the result from a multivariable regression model with global cognitive function as outcome and the pathologic variables, demographic variables and mtDNAcn as explanatory variables (y axis). Estimated coefficients are shown as dots and the line segments represent the respective 95% confidence intervals. Continuous variables were z-standardized. Categorical variables were dichotomized and the factor level and case numbers are denoted in brackets under the variable name. t-tests were applied to calculate p values. A total of n = 393 cases with complete observations of all variables were used to fit the model. (B) Same plot as in (A) but with neuronal proportion as additional variable in the model reducing the number of samples with complete observations to n = 287

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